Table 1.
Patient and Control Demographics and Baseline Characteristics
| Variables | PD N=416 | HC N=192 | P-value | |
|---|---|---|---|---|
| DEMOGRAPHIC | Age (y) | 61.7 (9.6) | 60.8 (11.3) | 0.3 |
| Sex | Male=272 (65.4%) Female=144 (34.6%) |
Male=123 (64.0%) Female =69 (35.9%) |
0.8 | |
| Education (y) | 15.5 (3.0) | 16.0 (2.9) | 0.06 | |
| APOE Ɛ4 Status | 0 alleles= 277 (73.3%) 1 allele= 92 (24.3%) 2 alleles= 9 (2.4%) Missing data=38 |
0 alleles= 129 (73.7%) 1 allele= 42 (24.0%) 2 alleles= 4 (2.3%) Missing data=17 |
>0.99 | |
| Age at Onset (y) | 59.7 (9.9) | NA | - | |
| Disease Duration (mo) | 6.7 (6.5) | NA | - | |
| MOTOR | UPDRS III Tremor | 0.5 (0.3) N=415 Missing data=1 |
0.03 (0.08) N=191 Missing data=1 |
<0.0001 |
| UPDRS III PIGD | 0.23 (0.22) N=415 Missing data=1 |
0.02 (0.09) N=191 Missing data=1 |
<0.0001 | |
| COGNITIVE | MOCA | 27.1 (2.3) N=413 Missing data=3 |
28.2 (1.1) N=192 |
<0.0001 |
| HVLT | 10 (−4,12) N=414 Missing data=2 |
11 (−4, 12) N=192 |
<0.001 | |
| SFT | 48.8 (11.6) N=415 Missing data=1 |
51.9 (11.3) N=192 |
<0.01 | |
| JLO | 13 (5,15) N=415 Missing data=1 |
14 (4, 15) N=192 |
0.06 | |
| LNS | 10.6 (2.6) N=415 Missing data=1 |
10.9 (2.6) N=192 |
0.1 | |
Data listed= mean (SD) for normally distributed variables or median (range) for non-normally distributed variables and frequency (%) for categorical variables. Missing Data noted in each cell where applicable.
Abbreviations: PD=Parkinson’s disease, HC=healthy controls, y= years, mo=months, APOE=apolipoprotein E, UPDRS= Unified Parkinson’s Disease Rating Scale, Tremor=Tremor sub score of UPDRS, PIGD= Postural instability and gait disturbance sub score of UPDRS, MOCA= Montreal Cognitive Assessment, HVLT= Hopkins Verbal Learning Test Discrimination Recognition Score , SFT= semantic fluency total score, JLO= Benton judgement of line orientation score, LNS= Letter-number sequencing score.