Table 3.
Incidence of infection at 1-year post-transplant, by intensity of desensitization (%).
| CLDKT | ILDKT* | ||||||
|---|---|---|---|---|---|---|---|
| Infection | None (n=260) | p-valuea | Overall (n=215) | Low (n=47) | Moderate (n=74) | High (n=94) | p-valueb |
| Median Number, (IQR) |
1 (0, 2) | <0.001 | 1 (0, 3) | 1 (0, 3) | 1 (1, 3) | 2 (1, 4) | <0.001 |
| Type |
|||||||
| Urinary Tract | 21.5 | 0.004 | 33.5 | 31.9 | 25.7 | 40.4 | 0.005 |
| Opportunistic | 10.8 | <0.001 | 21.9 | 21.3 | 20.3 | 23.4 | 0.008 |
| BK Virus | |||||||
| Viremia | 18.5 | 0.1 | 12.6 | 14.9 | 14.9 | 9.6 | 0.2 |
| BKVAN | 3.1 | 0.005 | 9.3 | 10.6 | 9.5 | 8.5 | 0.02 |
| Bloodstream | 5.4 | <0.001 | 19.1 | 14.9 | 14.9 | 24.5 | <0.001 |
| CMV | |||||||
| Viremia | 10.0 | 0.6 | 12.1 | 6.4 | 8.1 | 18.1 | 0.1 |
| Tissue-Invasive | 0.8 | 0.3 | 2.3 | 0.0 | 2.7 | 3.2 | 0.2 |
| Pneumonia | 4.6 | 0.002 | 12.1 | 8.5 | 10.8 | 16.0 | 0.005 |
| C. difficile | 3.8 | <0.001 | 13.5 | 8.5 | 9.5 | 19.1 | <0.001 |
| Other Viral | 3.5 | 0.007 | 9.8 | 6.4 | 10.8 | 10.6 | 0.02 |
| Surgical-Site | 3.8 | 0.2 | 6.5 | 0.0 | 5.4 | 10.6 | 0.03 |
| Gastroenteritis | 4.6 | 0.8 | 5.1 | 8.5 | 1.4 | 6.4 | 0.2 |
| Invasive Fungal | 2.3 | 0.02 | 7.0 | 2.1 | 2.7 | 12.8 | 0.001 |
| Skin/Soft Tissue | 2.3 | 0.1 | 5.1 | 2.1 | 4.1 | 7.4 | 0.1 |
*
Low (0-4 plasmaphereses), Moderate (5-9 plasmaphereses), and High (≥10 plasmaphereses)
a
p-value tests difference between overall ILDKT vs. CLDKT
b
p-value tests difference between intensity of desensitization vs. CLDKT
BKVAN; BK virus-associated nephropathy; C. difficile; clostridium difficile; CMV, cytomegalovirus; IQR, interquartile range.