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. Author manuscript; available in PMC: 2020 Nov 12.
Published in final edited form as: Psychosom Med. 2020 Nov-Dec;82(9):850–861. doi: 10.1097/PSY.0000000000000868

Figure 1. Research framework.

Figure 1.

A. In the heart-beat detection (HBD) task, subjects were asked to follow their heartbeats by pressing a keyboard key. Four interoceptive accuracy indexes were calculated. B. After each block, the participants rated their confidence about their performance; this score was used to derive the confidence and metacognition indexes. C. Heart-evoked potential (HEP) is a negativity presented between 200 and 400 ms after the R-peak wave of the heart beat. Two windows were selected: one between 200 and 300 ms, and the other one between 300 and 400 ms. D. Interoceptive regions of interest were selected from the brain volume analysis for the classification analysis: bilateral middle cingulate cortex (green), anterior cingulate cortex (red), postcentral gyrus (fuchsia) and insula (blue). E. Based on resting-state recordings, we calculated functional connectivity between the same areas considered for structural analysis. F. Classification linear discriminant analyses were performed with one feature selected from each level and dimension previously presented; a feature relevance analysis was then performed in order to determine the weight each feature had in the classification.