Table 2:

Inclusion and exclusion criteria for systematic reviews of adverse effects of statins

PICO Facet	Inclusion Criteria	Exclusion Criteria
Population (P)	General population of people taking statins	Specific populations or conditions (such as pregnancy or people with liver disease)
Intervention (I)	Statins	Statin combination therapy
Comparator (C)	Any	None excluded
Outcome (O)	More than one named adverse effect.	Only one named adverse effect or presents only information on adverse effects without naming any.