. Author manuscript; available in PMC: 2020 Oct 17.

Published in final edited form as: AJNR Am J Neuroradiol. 2018 Jan 18;39(3):427–434. doi: 10.3174/ajnr.A5507

Table 2:

¹H-MRS white matter parieto-occipital metabolite absolute concentrations, ratios, and water signal intensity, and T2 values in patients with MNGIE and healthy controls

	Patients with MNGIE (n = 7) (mean ± SD)	Healthy Controls (n = 9) (mean ± SD)	P Value^a
Metabolite concentrations (mM)
NAA	6.98 ± 0.79	9.81 ± 0.94	<.001^a,c
Cr	4.15 ± 0.48	5.97 ± 0.55	<.001^a,c
Cho	1.53 ± 0.23	1.89 ± 0.24	.01^a
mIns	4.46 ± 1.14	5.44 ± 0.76	.06^a
Metabolite ratios
NAA/Cr	1.85 ± 0.18	1.80 ± 0.11	.57^b
Cho/Cr	0.39 ± 0.06	0.33 ± 0.04	.04^b
mIns/Cr	0.99 ± 0.27	0.85 ± 0.08	.16^b
Water signal (a.u.)
S_BW (0)	(14.0 ± 9.0)×10¹⁰	(10.8 ± 2.0)×10¹⁰	.370
S_CSF(0)	(4.0 ± 7.5)×10¹⁰	(1.3 ± 0.6)×10¹⁰	.23^a
T2 water
T_2BW (ms)	112 ± 24	75 ± 8	.001^a,c
T_2CSF(ms)	520 ± 185	776 ± 344	.098^a

Note:—a.u. indicates arbitrary units; S_BW(0) and S_CSF (0), water signals corresponding to brain and cerebrospinal water, respectively; T_2BW and T_2CSF, water relaxation times corresponding to brain and cerebrospinal water, respectively.

Statistical significance was set at P < .0125 after Bonferroni correction for multiple comparisons.

Statistical significance was set at P < .0167 after Bonferroni correction for multiple comparisons.

Significant.