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. Author manuscript; available in PMC: 2020 Dec 28.
Published in final edited form as: J Thromb Haemost. 2020 Oct 5;18(12):3359–3370. doi: 10.1111/jth.15095

FIGURE 3.

FIGURE 3

Normal heart function in mice with JAK2V617F-mutant blood cells and wild-type vascular endothelial cells. A, Experimental scheme to generate a chimeric murine model with JAK2V617F-mutant blood cells and wild-type vascular endothelium. B, Blood counts in recipient mice of either Tie2-cre control (gray) or Tie2FF1 (black) marrow cells 22 weeks after transplantation (n = 5 mice in each group). C, Serial measurements of ejection fraction, fractional shortening, and left ventricular (LV) volumes in recipients of Tie2-cre control marrow (dotted line) and recipients of Tie2FF1 marrow (black line; n = 5 mice in each group). D, Ly-6Chi monocytes in recipient mice of Tie2-Cre control (gray) or Tie2FF1 (black) marrow cells 22 weeks after transplantation (n = 5 mice in each group). E, Representative hematoxylin/eosin staining of intramyocardial coronary arterioles (arrow) in a recipient mouse of Tie2FF1 marrow (magnification 40×). Statistical significance for B–D was determined by the Mann-Whitney test. *P < .05