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Impact of the PIGQ variants on the expression of GPI-APs. Flow cytometry analysis of fibroblasts derived from subject 3b (top row) and subject 5 (bottom row) and compared to healthy controls and parental derived cell-lines, respectively. Subject cell lines were further transfected with empty lentivirus or lentivirus expressing WT PIGQ cDNA. Fluorescently labeled proaerolysin “FLAER” directly binds the GPI-anchor, whereas CD73 and CD109 stain for GPI-APs
