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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: J Neurosci. 2008 Jan 30;28(5):1109–1117. doi: 10.1523/JNEUROSCI.4853-07.2008

Figure 8. Ascl1a is required for proliferation of Müller glia.

Figure 8

Morpholinos were electroporated into injured −1016 retinas on day 0 and fish were housed in BrdU treated water from 36-60 hours post injury to label dividing cells. The fish recovered until day 10 when eyes were harvested. The control morpholino does not prevent treated cells from labeling with BrdU (arrowheads, top 3 control panels). Morpholinos targeting ascl1a (ascl1a and ascl1a5′UTR) prevent cells from labeling with BrdU (arrows in panels ascl1a and ascl1a5′UTR). Some cells are able to proliferate, but were not treated with morpholino (arrowheads panels ascl1a and ascl1a5′UTR). ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer.