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. Author manuscript; available in PMC: 2021 Jan 26.
Published in final edited form as: Cell. 2020 Dec 9;184(1):120–132.e14. doi: 10.1016/j.cell.2020.12.006

Figure 3. Coronaviruses co-opt an extensive network of human proteins and pathways to complete their life cycle.

Figure 3.

(A) Network analysis of human coronavirus host factors for all significant screening hits using the STRING-db protein:protein interaction network. Nodes are subdivided by number of virus screens by color and size for which the node was significant. Highly interconnected and functionally related genes are further highlighted in gray.

(B-G) Comparative pathway-focused heatmaps showing enriched and depleted sgRNAs across all CRISPR screens.