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. Author manuscript; available in PMC: 2021 Jan 26.
Published in final edited form as: Cell. 2020 Dec 9;184(1):120–132.e14. doi: 10.1016/j.cell.2020.12.006

Figure 4. Validation of high-confidence Coronaviridae host factors.

Figure 4.

(A) Candidate validation in Huh-7.5 cells with SARS-CoV-2 infection at 33 °C.

(B) Candidate validation in Huh-7.5 cells with HCoV-OC43 infection at 33 °C.

(C) Candidate validation in Huh-7.5 cells with HCoV-NL63 at 33 °C.

(D) Candidate validation in Huh-7.5 cells with HCoV-229E at 37 °C.

(E) Heatmap representation of data from panels A-D. The ACE2 receptor (SARS-CoV-2, HCoV-NL-63) and the ANPEP receptor (HCoV-229E) are shown separately.