Table 2.

Summary of clinically relevant statistics of autoantibody-antigen reactivity combinations that are from 100 to 90% specific with ASD diagnosis in the training and validation set (combined data).

Pattern	Training ASD + /subgroup	Validation ASD + /subgroup	ASD/ Subgroup	Precision	Precision drop	Total ASD % (n=450)	Fisher’s exact test p-value	OR (95% CI)a	OR p-value
CRMP1+GDA	15/15	4/4	19/19	1.00	0.00	4.2	<0.0001	31.04 (1.8678 to 516.0620)	0.0166
CRMP1+CRMP2	12/12	4/4	16/16	1.00	0.00	3.6	0.0001	26.08 (1.5596 to 436.4170)	0.0233
NSE+STIP1	8/8	6/6	14/14	1.00	0.00	3.1	0.0005	22.82 (1.3565 to 383.9379)	0.0299
CRMP2+STIP1	6/6	3/3	9/9	1.00	0.00	2	0.0064	14.78 (0.8573 to 254.8841)	0.0637
LDHA+YBOX	1/1	5/5	6/6	1.00	0.00	1.3	0.0393	10.04 (0.5640 to 178.9532)	0.1164
LDHB+YBOX	2/2	4/4	6/6	1.00	0.00	1.3	0.0393	10.04 (0.5640 to 178.9532)	0.1164
GDA+YBOX	5/5	1/1	6/6	1.00	0.00	1.3	0.0393	10.04 (0.5640 to 178.9532)	0.1164
STIP1+YBOX	4/5	7/7	11/12	0.92	0.08	2.4	0.0161	8.56 (1.1010 to 66.7020)	0.0402
CRMP1+STIP1	15/17	3/3	18/20	0.90	0.10	4	0.0022	7.10 (1.6371 to 30.8292)	0.0088

Abbreviations: ASD, Autism Spectrum Disorders; OR: odds ratio; CI, confidence interval. CRMP1 and CRMP2, collapsin response mediator proteins 1 and 2; GDA, guanine deaminase; NSE, neuron specific enolase; LDHA-B, lactate dehydrogenase A and B; STIP1, stress induced phosphoprotein 1 and YBOX, Y-box binding protein 1.

Fisher’s exact (two-sided) was used to evaluate the association of the patterns with ASD diagnosis and p-values > 0.05 were bolded and considered significant.

^aA 0.5 continuity correction was applied to OR calculations for observations with zero cell counts, since all the patterns in this table are ASD specific, all the TD cells were equal to zero, the correction was applied to all OR calculations in this table.