Skip to main content
. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Nat Biomed Eng. 2021 Feb 8:10.1038/s41551-020-00675-9. doi: 10.1038/s41551-020-00675-9

Fig. 5 |. PC7A and cGAMP show synergistic antitumor efficacy in tumor-bearing mice.

Fig. 5 |

(a-c) MC38 and (d-f) TC-1 tumor-bearing mice were injected intratumorally with 5% glucose (mock), cGAMP (2.5 μg), PC7A (50 μg), or cGAMP-loaded PC7A nanoparticles at indicated time points. Mean tumor volume (a, d), Kaplan–Meier survival curves (b, e), and spider plots of individual tumor growth curves (c, f) are shown. PC7A NP or cGAMP alone offers some degree of immune protection. cGAMP-loaded PC7A NP confers a synergistic anti-tumor immune response, with significantly improved survival and 4 of 7 mice in the MC38 model tumor-free. In tumor growth studies, values represent mean ± SEM, n=7 (mock), n=6 (cGAMP), n=7 (PC7A), n=7 (cGAMP-PC7A) of biologically independent mice in each tumor model, two-tailed Student’s t-test (versus mock). In survival studies, Mantel–Cox test.