Figure 4. Selective diurnal metabolic inflexibility of cardiac triglyceride synthesis in obese mice.

Hearts were isolated from mice (at ZT5 and ZT17) that were fed either a control or high fat diet in an ad libitum fashion for 20-wks, followed by assessment of cardiac metabolism ex vivo. (A) Rates of cardiac glucose oxidation (i), fatty acid oxidation (ii), [¹⁴C]-labelled lactate release (iii), net lactate release (iv), net glycogen synthesis (v), and net triglyceride synthesis (vi) in control mice (n=8–10). (B) Rates of cardiac glucose oxidation (i), fatty acid oxidation (ii), [¹⁴C]-labelled lactate release (iii), net lactate release (iv), net glycogen synthesis (v), and net triglyceride synthesis (vi) in high fat fed mice (n=8–11).