Figure 7. Time-of-day-restricted feeding partially reverses adverse remodeling markers in hearts of high fat fed mice.

(A) Biventricular weight to tibia length (BVW/TL) ratio was determined in mice that were fed either a control or high fat diet in an ad libitum fashion for 18-wks, followed by food access only during the 12-hr dark (active) phase for 2-wks (n=5). (B) Cardiomyocyte size was determined in mice that were fed either a control or high fat diet in an ad libitum fashion for 18-wks, followed by food access only during the 12-hr dark (active) phase for 2-wks (n=5). (C) Cardiac fibrosis was determined in mice that were fed either a control or high fat diet in an ad libitum fashion for 18-wks, followed by food access only during the 12-hr dark (active) phase for 2-wks (n=5). (D) Cardiac steatosis was determined in mice that were fed either a control or high fat diet in an ad libitum fashion for 18-wks, followed by food access only during the 12-hr dark (active) phase for 2-wks (n=5). Data are reported as mean ± SEM.