Table 1:
Baseline clinical and demographic characteristics
| Variable | Cross-sectional cohort | Longitudinal cohort | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Total cohort Median (IQR) (N=101) | NC Median (IQR) (N=39) | MCI Median (IQR) (N=41) | PDD Median (IQR)) (N=21) | Kruskal-Wallis p value | N | Total cohort median (IQR) (N=64) | Normal Cognition median (IQR) (N=32) | Cognitive Impairment median (IQR) (N=32) | Wilcoxon-Mann-Whitney p value | |
| Education (years) | 101 | 16 (14–18) | 18 (16–18) | 16 (14–18) | 16 (14–18) | 0.26 | 64 | 16 (14–18) | 18 (16–18) | 16 (14–18) | 0.10 |
| Sex (% male) | 101 | 66.3 | 53.8 | 78 | 66.7 | 0.07 | 64 | 70.3 | 56.3 | 84.4 | 0.01 |
| Disease duration (years) | 101 | 9 (6–13) | 9 (6–11) | 10 (6–14) | 11 (7–18) | 0.15 | 64 | 14 (10–19) | 13 (10–19) | 16 (10–18) | 0.31 |
| GDS-15 | 99 | 2 (1–4) | 1 (0–2) | 3 (2–5) | 3 (2–4) | <0.001 | 64 | 2 (1–4) | 1 (0.25–2) | 3 (2–5) | 0.003 |
| UPDRS III | 100 | 30 (23–41) | 23 (17–32) | 33 (24–46) | 42 (32–51) | <0.001 | 64 | 28 (20–40) | 23 (18–32) | 34 (24–44) | 0.003 |
| LEDD | 101 | 600 (400–1025) | 550 (350–913) | 641 (450–1332) | 800 (400–1030) | 0.21 | 64 | 575 (400–973) | 480 (300–922) | 600 (400–1000) | 0.22 |
| Age at test (years) | 101 | 72 (67–76) | 70 (64–75) | 72 (69–76) | 76 (72–80) | 0.01 | 64 | 71 (64–75) | 70 (63–72) | 72 (71–77) | 0.01 |
| DRS-2 | 101 | 135 (129–140) | 140 (139–141) | 134 (131–137) | 121 (112–128) | <0.001 | 64 | 138 (133–141) | 140 (139–141) | 134 (130–137) | <0.001 |
| MoCA | 101 | 24 (21–27) | 27 (25–28) | 23 (22–25) | 17 (16–21) | <0.001 | 64 | 25 (23–27) | 27 (26–29) | 23.0 (20–24) | <0.001 |
| Clock Drawing Test | 87 | 6 (5–7) | 7 (6–7) | 5 (4–6) | 4 (3–6) | <0.001 | 61 | 5 (3–8) | 5 (3–8) | 7 (3–9) | 0.51 |
| Boston Naming Test | 69 | 58 (56–59) | 59 (57–60) | 58 (55–59) | 56 (26–59) | 0.04 | 52 | 59 (57–59) | 59 (59–60) | 56 (53–59) | <0.001 |
| JOLO | 83 | 24 (20–26) | 24 (22–26) | 24 (20–26) | 16 (13–18) | 0.001 | 59 | 24 (20–26) | 25 (23–28) | 22 (20–26) | 0.02 |
| Trails A | 80 | 45 (35–70) | 38 (31–45) | 60 (40–81) | 102 (77–113) | <0.001 | 58 | 43 (32–57) | 35 (28–44) | 47 (39–67) | 0.002 |
| Trails B | 79 | 97 (77–154) | 79 (61–93) | 131 (96–209) | 272 (167–300) | <0.001 | 57 | 88 (73–129) | 79 (59–88) | 122 (95–180) | <0.001 |
| Symbol Digit Modalities Test | 90 | 31 (20–40) | 40 (35–45) | 23 (19–31) | 13 (8–15) | <0.001 | 61 | 35 (23–41) | 41 (35–45) | 29 (22–35) | <0.001 |
| LNS | 88 | 9 (7–11) | 10 (9–12) | 8 (6–9) | 5 (4–7) | <0.001 | 64 | 9 (7–11) | 10 (9–12) | 8 (6–9) | 0.002 |
| HVLT immediate recall | 90 | 21 (15–26) | 25 (21–29) | 19 (14–24) | 13 (7–20) | <0.001 | 64 | 23 (16–27) | 27 (24–29) | 17 (14–23) | <0.001 |
| HVLT delayed recall | 90 | 7 (3–9) | 8 (6–11) | 5 (2–8) | 0 (0–7) | <0.001 | 64 | 7 (5–9) | 9 (7–11) | 5 (4–7) | <0.001 |
| HVLT recognition discrimination | 90 | 10 (8–11) | 11 (10–12) | 9 (8–10) | 8 (5–10) | <0.001 | 64 | 10 (9–11) | 11 (10–12) | 10 (8–11) | 0.012 |
| FAS fluency | 90 | 41 (30–51) | 47 (40–58) | 36 (26–44) | 27 (19–35) | <0.001 | 64 | 41 (35–50) | 44 (39–62) | 36 (25–44) | 0.002 |
| Animal fluency | 90 | 16 (12–20) | 20 (16–23) | 15 (11–17) | 9 (7–12) | <0.001 | 64 | 17 (13–22) | 21 (18–23) | 15 (12–18) | <0.001 |
| ADCS-ADLi | 98 | 73 (64–77) | 75 (73–78) | 70 (64–77) | 60 (45–65) | <0.001 | 63 | 74 (69–77) | 75 (72–77) | 72 (59–77) | 0.11 |
| PDAQ-15 | 99 | 49 (38–55) | 55 (50–59) | 48 (40–54) | 27 (20–39) | <0.001 | 64 | 53 (44–57) | 55 (50–58) | 48 (35–57) | 0.008 |