Table 2:

CDR-SOB and CDR domain scores at baseline

CDR	Cross-sectional cohort								Longitudinal cohort
	Cohort Median (IQR)	Min	Max	Floor Effect*	NC Median (IQR)	MCI Median (IQR)	PDD Median (IQR)	Kruskal- Wallis p value¶	Cohort mean (SD)	NC mean (SD)	CI mean (SD)	Wilcoxon- Mann- Whitney p value
SOB	1.5 (0.5–3.5)	0	13	15.8	0.5 (0–1.5)	2 (1–3)	6 (3.8–9.5)	<0.001ǁ	1 (0.5–2.5)	0.5 (0–1.4)	2 (1–5)	0.001
Memory	0.5 (0–1)	0	3	27.7	0 (0–0.5)	0.5 (0.5–1)	1 (1–1.5)	<0.001ǁ	0.5 (0–0.5)	0.3 (0–0.5)	0.5 (0.5–1)	<0.001
Orientation	0 (0–0.5)	0	2	50.5	0 (0–0.5)	0 (0–0.5)	1 (0.5–1.5)	<0.001‡§	0 (0–0.5)	0 (0–0.5)	0 (0–0.5)	0.39
Judgment	0.5 (0.5–1)	0	2	22.8	0 (0–0.5)	0.5 (0.5–1)	1 (1–2)	<0.001ǁ	0.5 (0–0.5)	0.3 (0–0.5)	0.5 (0.5–1)	<0.001
Community	0 (0–0.5)	0	2	57.4	0 (0–0)	0 (0–0.5)	1 (0.5–1.5)	<0.001ǁ	0 (0–0.5)	0 (0–0)	0 (0–1)	0.03
Hobbies	0 (0–0.5)	0	3	55.5	0 (0–0)	0 (0–0.5)	1 (0.8–2)	<0.001ǁ	0 (0–0.5)	0 (0–0)	0.5 (0–1)	0.001
Personal Care	0 (0–0)	0	2	78.2	0 (0–0)	0 (0–0)	1 (0–2)	<0.001‡§	0 (0–0)	0 (0–0)	0 (0–1)	0.009

^¶Bonferroni correction applied to account for multiple comparison across groups

^*Floor effect represents the percentage of the total cohort with a value of 0 for the domain score

^†NC significantly different than MCI

^‡NC significantly different than PDD

^§MCI significantly different than PDD

^ǁAll groups significantly different from one another