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. Author manuscript; available in PMC: 2021 Apr 16.
Published in final edited form as: Int J Obes (Lond). 2021 Jan 26;45(4):795–807. doi: 10.1038/s41366-021-00742-4

Figure 1. SA knock-in allele confers resistance to body weight gain and reduces susceptibility to atrial fibrillation on a high-fat diet.

Figure 1.

(A) Body weight of WT-HFD and SA-HFD mice after 6 weeks of HFD; (B) changes in body weight for WT-HFD and SA-HFD mice after 6 weeks of HFD. Data are presented as means ± SEM (WT-HFD n=27, SA-HFD n=13; *p<0.05, ****p<0.0001 vs WT-HFD). (C) Density of pre-atrial contractions; (D) severity of AT/AF based on a score of 0 (none) to 4 (severe); and (E) representative ECGs following injection of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg). Data are presented as means ± SEM (WT Chow n=22, WT-HFD n=23, SA-HFD n=14; *p<0.05, **p<0.01, ***p<0.001 vs WT-HFD).