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. Author manuscript; available in PMC: 2021 Apr 16.
Published in final edited form as: Int J Obes (Lond). 2021 Jan 26;45(4):795–807. doi: 10.1038/s41366-021-00742-4

Figure 2. Inhibition of INa,L with Mexiletine reduces susceptibility to atrial fibrillation under conditions of diet-induced obesity.

Figure 2.

(A) Density of pre-atrial contractions; (B) severity of AT/AF based on a score of 0 (none) to 4 (severe) following injection of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg); and (C) representative EKGs from 6-week high fat diet mice injected with saline or mexiletine followed by exposure to epinephrine/caffeine. Data are presented as means ± SEM (WT-HFD n=23, WT+HFD+Mex n=8) (*p<0.05 vs WT-HFD).