Skip to main content
. Author manuscript; available in PMC: 2021 Apr 16.
Published in final edited form as: Int J Obes (Lond). 2021 Jan 26;45(4):795–807. doi: 10.1038/s41366-021-00742-4

Figure 5. Attenuating body weight gain on HFD partially mitigates susceptibility to AF in Wild-type mice compared to SA knock-in mice.

Figure 5.

(A) Average daily food intake of WT-HFD and SA-HFD mice on a high-fat diet. Data are presented as means ± SEM (WT-HFD n=15, SA-HFD n=5; ****p<0.0001 vs WT-HFD). Wild type mice were pair-fed (WT-HFD-PF) the same amount of HFD as SA-HFD mice for 6 weeks and (B) body weight (C) changes in body weight measured. (D) changes in percent fat and (E) lean mass measured using EchoMRI. Data are presented as means ± SEM (WT-HFD-PF n=9, SA-HFD n=10). (F) Density of pre-atrial contractions and (G) severity of AT/AF based on a score of 0 (none) to 4 (severe) measured following injection of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg). Data are presented as means ± SEM (WT-HFD-PF n=7, SA-HFD n=14; **p<0.01 vs WT-HFD-PF).