Fig 2.

GSK2593074A (GSK’074) attenuates progression of existing aneurysmal dilation. A, Experimental design. C57BL/6J mice underwent ultrasound examination of the infrarenal abdominal aorta at baseline and weekly after aneurysm induction for 28 days. Daily intraperitoneal injections of GSK’074 (4.65 mg/kg) or dimethylsulfoxide (DMSO)-control started 7 days after aneurysm induction. B, Representative ultrasound images of the infrarenal aorta. Red outlines the external diameter and yellow outlines the luminal diameter. C, Maximum external diameter measured from ultrasound images over the course of the study period. Data are presented as mean ± standard error. Two-way analysis of variance with a post-hoc Tukey’s test was performed. D, Aortic expansion index over the course of the study period. Data are presented as mean ± standard error. Two-way analysis of variance with a post hoc Tukey’s test was performed. E, Mice were euthanized 28 days after aneurysm induction and the percentage increase in maximal external aortic diameter measured by digital caliper was calculated. The bars indicate 95% confidence intervals. A two-tailed Student t-test was performed. F, Images of aortas of both groups. n = 6 for each group. *P ≤ .05. AAA, abdominal aortic aneurysm.