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. Author manuscript; available in PMC: 2021 Nov 17.
Published in final edited form as: Mol Psychiatry. 2021 Feb 15;26(9):4633–4651. doi: 10.1038/s41380-021-01038-9

Fig. 7. Light-induced Drp1 oligomerization restores gamma oscillations in sdy slices.

Fig. 7.

Hippocampal slices were prepared from sdy mice injected with designated lentivirus and recorded in the CA3 region for LFPs; gamma oscillations were induced by perfusion with 20 μM CCH. (A) Sample traces of local field potentials recorded without (top) or at 10 min after (middle, bottom) light stimulation. (B) Mean power spectral density of LFPs. (C) Integrated power spectral density of LFPs at 20–80 Hz. One way ANOVA on ranks (H = 40.038, DF = 4, p = 0.001) was used to compare across groups; Student’s t-test was used to compare unstimulated and light-stimulated sdy mice transduced with Cry2 and CIB1 virus; Mann-Whitney U test was used to compare unstimulated and light-stimulated sdy slices transduced with Cry2-Drp1 and CIB1-Drp1 viruses, and sdy vs. WT; n in the bars indicates the number of brain slices from 4 animals. Data are presented as mean ± SEM; ** p < 0.01; *** p < 0.001.