Fig. 5.

Evaluation of PKD isoform expression in urothelial bladder carcinoma tissues using the TCGA bladder cancer dataset. PKD gene expression was evaluated using the level 3 RNA-Seq count dataset from the TCGA bladder cancer database, which includes 131 patients with urothelial carcinoma and 19 normal urothelial samples. Mean expression of PKD2 gene is significantly upregulated in bladder tumor tissues (a) and in the four molecular subtypes of bladder cancer tissues (b). P < 0.003 for the bladder cancer group vs. the normal urothelium group. Mean expression of PKD1 gene is clearly downregulated in the four molecular subtypes of bladder cancer tissues (c). P < 0.001 for the bladder cancer group vs. the normal urothelium group. PKD3 gene expression is only moderately upregulated in the tumor tissues of the four molecular subtypes of bladder cancer patients (d). P = 0.769 for the bladder cancer group vs. the normal urothelium group