Skip to main content
. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Cell Mol Life Sci. 2021 Feb 2;78(9):4125–4141. doi: 10.1007/s00018-021-03776-z

Fig. 2. GAF functions in conjunction with ATP-dependent chromatin remodelers to establish nucleosome-free regions of chromatin.

Fig. 2

(a) GAF interacts with nucleosomal DNA and recruits chromatin remodelers. In an ATP-dependent reaction remodelers translocate nucleosomes and establish “nucleosome-free” regions of chromatin that are hypersensitive to various nucleases. This facilitates the recruitment of other transcription factors. (b) GAF interacts with ATP-dependent chromatin remodelers of different subfamilies: SWI/SNF (PBAP and BAP), ISWI (NURF, ACF and ToRC), CHD (dNURD). Contacts established by indirect methods are indicated by dotted blue lines; direct partners (E(bx), ISWI and MEP-1) are indicated by solid black lines.