Table 2.

Coordinates of activated regions

Brain region(s)	Extent (mm3)	Max t	MNI coordinates
			x	y	z
Linguistic demand
Left fusiform gyrus, inferior temporal gyrus, lingual gyrus, inferior and middle occipital lobe	33,432	13.61	−37	−71	−12
Left IFG pars opercularis and triangularis, inferior frontal sulcus, inferior frontal junction, precentral gyrus, anterior insula	30,224	7.20	−43	15	20
Right inferior occipital lobe	17,824	6.51	36	−78	−11
Bilateral thalamus, basal ganglia, midbrain	13,928	7.44	−3	−12	1
Right IFG ascending ramus of the Sylvian fissure, inferior frontal junction, anterior insula	12,008	8.10	41	19	17
Bilateral cerebellum	6,792	6.44	3	−71	−28
Right pre-SMA/anterior-mid cingulate	5,680	6.20	9	24	38
Negative linguistic demand
Bilateral precuneus, posterior cingulate	37,016	9.86	−1	−53	29
Left angular gyrus	16,616	10.46	−45	−65	30
Right supramarginal gyrus, postcentral gyrus	15,408	5.21	48	−27	44
Right angular gyrus	8,672	8.24	47	−66	31
Bilateral ventromedial prefrontal cortex	7,280	5.64	2	49	−6
Right posterior insula	5,712	5.84	41	−6	5
Interaction of domain by difficulty
Left IFG pars triangularis and orbitalis, superior temporal gyrus, STS, middle temporal gyrus, hippocampus	45,112	7.22	−47	−4	−9
Bilateral ventromedial prefrontal cortex, superior frontal gyrus	37,008	8.61	−1	50	18
Bilateral precuneus, posterior cingulate	26,840	7.70	−1	−51	28
Right superior temporal gyrus, STS, middle temporal gyrus	15,584	6.84	60	−14	−12
Negative interaction of domain by difficulty
Much of the bilateral multiple demand network, cerebellum	232,624	10.66	7	−53	16
Left dorsal precentral gyrus and sulcus, superior frontal sulcus, pre-SMA, anterior-mid cingulate	14,776	7.47	−20	−1	54
Left anterior insula, basal ganglia	7,672	6.84	−28	18	8
Right thalamus	7,584	7.21	16	−15	11

Coordinates are centers of mass.