Figure 5-.

NMDAR-NR2B neurotransmission increases across the cortical hierarchy and across primate evolution. A. Delay cells in rhesus monkey dlPFC rely on NMDAR-NR2B neurotransmission, with relatively little influence from AMPAR. Thus, blockade of AMPAR with CNQX has little effect, while blockade of NMDAR with NR2B subunits with Ro25–6981 markedly reduces Delay cell firing as the monkey performs a working memory task. B. In contrast, neurons in rhesus monkey V1 depend on AMPAR more than NMDAR. Neurons responding to a bar of light greatly reduce their firing when AMPAR are blocked with CNQX, but show little effect when NMDAR-NR2B are blocked by Ro25–6981. C. Increased expression of GRIN2B, which encodes for the NMDAR-NR2B, in the dlPFC across primate evolution. D. GRIN2B expression increases across the human cortical hierarchy. Panels A and B from (S. T. Yang et al., 2018) with permission. Panel C from (Muntane et al., 2015) with permission. Panel D from (Burt et al., 2018) with permission.