Socioeconomic factors (stable housing, transportation, living with responsible adult who can support infusions)
Risk of misusing PICC line
Lack of tamper-evident mechanism
Willingness of ID physician to follow the patient as an outpatient
Risk of incomplete antibiotic course
Requirement of behavioral contract
Need for mental health or substance use disorder treatment
Lack of data on outcomes for OPAT in PWID
Risk of being sued
Inadequate Medicare coverage for non-homebound patients15
Lack of existing models and guidance or research