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. Author manuscript; available in PMC: 2021 Jul 2.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2021 Feb 11;186(1):16–27. doi: 10.1002/ajmg.b.32834

FIGURE 1.

FIGURE 1

Manhattan plot for chromosomes 1–22 for PTSD. ● denotes reported signals from the original GWAS and the remain symbols and colors denote DISTMIX2 imputed signals. Among imputed signals blue denotes info<0.2, red denotes 0.2 < info<0.4, cyan denotes 0.4 < info<0.6, brown denotes 0.6 < info<0.8, orange denotes info>0.8, □ denotes MAF <0.05%, △ denotes 0.05% < MAF < 0.5%, ▽denotes 0.5% < MAF < 1%, + denotes 1% < MAF < 2%, ◊ denotes 2% < MAF < 5%, x denotes 5% < MAF < 10% and * denotes 10% < MAF < 50%. The red line is the default genome-wide threshold of p = 5*10e-8, which is applicable common SNPs with moderate to large Info values. The purple line at p = 10e-12 is the threshold to be used for rare and/or low Info variants. GWAS, genome-wide association studies; MAF, minor-AF; PTSD, post-traumatic stress disorder; SNPs, single nucleotide polymorphisms