Skip to main content
. Author manuscript; available in PMC: 2021 May 20.
Published in final edited form as: Nature. 2021 Apr 7;593(7857):101–107. doi: 10.1038/s41586-021-03420-7

Extended Data Figure 8. Composition, organization, and entropy of the CHM13 D8Z2 α-satellite HOR array.

Extended Data Figure 8.

a) HOR composition and organization of the chromosome 8 α-satellite array as determined via StringDecomposer42. The predominant HOR subtypes (4-, 7-, 8-, and 11-mers) are shown, while those occurring less than 15 times are not (see Methods for absolute quantification). The entropy of the D8Z2 HOR array is plotted in the bottom panel and reveals that the hypomethylated and CENP-A-enriched regions have the highest consistent entropy in the entire array. b) Organization of α-satellite monomers within each HOR. The initial monomer of the 4- and 7-mer HORs is a hybrid of the A and E monomers, with the first 87 bp the A monomer and the subsequent 84 bp the E monomer. c) Abundance of the predominant HOR types within the D8Z2 HOR array as determined via StringDecomposer42.