a. Representative images of Iba-1 immunoreactive microglia were present in the ipsilateral striatum, substantia nigra and frontal cortex of saline and PFFs injected mice. High magnification examples of Iba-1 immunoreactive microglia in the striatum. b. Quantification of microglia morphology and c. microglia numbers/mm2 in the ipsilateral hemisphere to PFF injection in the striatum, substantia nigra and frontal cortex (area/perimeter). Wildtype Saline, n = 5; NSG Saline n = 4–6, wildtype PFFs, n = 6–10; NSG PFFs, n = 3–5; NSG PFF T n = 4–7; NSG PFF B n = 4–9).