Table 1.

DS-affinity autoantigenome from human A549 cells.

# Pep.	Gene	Protein	COVID		A549 infection		Interactome	DS-affinity		AutoAg ref.
			Up	Down	Up	Down		1.0 M	0.5 M
2	A2M	Alpha-2-macroglobulin		D					+	[54]
2	ACLY	ATP-citrate synthase	U	D	U	D			+	[55]
9	ACTA2	Actin, aortic smooth muscle	U	D	U	D		+		[56]
8	ACTB	Actin, cytoplasmic 1	U	D	U	D		+		[57]
5	ACTBL2	Beta-actin-like protein 2	U	D	U	D		+		[57]
20	ACTN1	Alpha-actinin-1	U	D	U	D			+	[58]
20	ACTN4	Alpha-actinin-4	U	D	U				+	[56]
2	ADSS2	Adenylosuccinate synthetase isozyme 2	U		U				+
3	AFP	Alpha-fetoprotein		D					+	[59]
2	AGRN	Agrin	U		U			+		[60]
6	AHCY	Adenosylhomocysteinase		D		D			+
5	AKR1B1	Aldose reductase (diabetic complication)	U	D	U	D	Orf3		+	[61]
6	ALB	Putative uncharacterized protein ALB	U	D	U	D		+		[62]
23	ALDH1A1	Retinal dehydrogenase	U	D	U	D			+	[63]
5	ALDH2	Aldehyde dehydrogenase, mitochondrial	U	D					+	[64]
5	ALDH3A1	Aldehyde dehydrogenase, dimeric NADP-preferring, ALDH3	U	D	U	D			+
9	ALDOA	Fructose-bisphosphate aldolase	U	D	U	D			+	[65]
6	ANP32A	Acidic leucine-rich nuclear phosphoprotein 32 family member A	U	D		D		+
13	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B, APRIL		D		D		+		[66]
3	ANP32C	Acidic leucine-rich nuclear phosphoprotein 32 family member C, PP32R1						+
4	ANP32E	Acidic leucine-rich nuclear phosphoprotein 32 family member E	U	D	U	D		+
4	ANXA2	Annexin A2	U	D	U				+	[67]
13	ANXA2P2	Annexin A2 pseudogene 2	U	D	U				+	[67]
10	ANXA3	Annexin A3	U	D	U				+	[68]
5	ANXA4	Annexin IV	U	D	U	D			+	[69]
15	ANXA5	Annexin A5	U	D	U	D	Orf3		+	[70]
8	ANXA6	Annexin VI	U	D					+	[71]
8	AP3B1	AP-3 complex subunit beta-1	U				E	+
2	AP3B2	AP-3 complex subunit beta-2						+		[72]
8	AP3D1	AP-3 complex subunit delta-1	U	D				+
4	APEX1	DNA-(apurinic or apyrimidinic site) endonuclease	U	D	U	D			+	[73]
4	ASPH	Aspartyl/asparaginyl beta-hydroxylase	U	D		D		+
2	ATP2A2	ATP Sarcoplasmic/ER calcium transporting 2 (cardiac Ca2+ ATPase, heart failure)	U				Nsp4	+		[74]
13	ATP5B	ATP synthase subunit beta, mitochondrial, ATP5F1B	U	D			Nsp6	+		[75]
3	BRIX1	Ribosome biogenesis protein BRX1 homolog						+
8	C1QBP	Complement C1q-binding protein, mitochondrial matrix protein p32		D		D		+		[76]
10	CALR	Calreticulin	U	D	U				+	[77]
7	CANX	Calnexin	U	D	U	D	Nsp4	+		[78]
2	CAP1	Cyclase associated actin cytoskeleton regulatory protein 1	U	D			Orf3		+
2	CAPN1	Calpain-1 catalytic subunit							+
2	CAPZB	F-actin-capping protein subunit beta		D					+	[79]
5	CCT8	T-complex protein 1 subunit theta	U	D	U	D			+	[80]
3	CDK11A	Cyclin-dependent kinase 11A, CDC2L2	U					+
3	CEBPZ	CCAAT/enhancer-binding protein zeta	U					+
4	CLIC1	Chloride intracellular channel protein 1	U	D					+	[81]
4	CLTC	Clathrin heavy chain 1	U	D		D		+		[3]
2	CLTCL1	Clathrin heavy chain 2						+
2	COPA	Coatomer subunit alpha	U	D	U	D		+		[82]
2	CPNE3	Copine-3	U	D					+
2	CTR9	RNA polymerase-associated protein CTR9 homolog	U	D		D		+
4	DCAF1	DDB1- and CUL4-associated factor 1, VPRBP	U	D	U			+
13	DDB1	DNA damage-binding protein 1	U	D	U	D		+		[3]
3	DDX17	Probable ATP-dependent RNA helicase DDX17	U	D	U			+
7	DDX18	ATP-dependent RNA helicase DDX18	U					+
5	DDX21	Nucleolar RNA helicase 2 (RH II/Gu)	U	U			N	+		[83]
4	DDX27	Probable ATP-dependent RNA helicase DDX27	U		U			+
3	DDX30	ATP-dependent RNA helicase DHX30, DDX30						+
8	DDX48	Eukaryotic initiation factor 4A-III, EIF4A3						+
4	DDX5	Probable ATP-dependent RNA helicase DDX5	U	D				+
16	DDX9	ATP-dependent RNA helicase A, DHX9						+		[84]
12	DHX15	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15		D				+
4	DHX36	Probable ATP-dependent RNA helicase DHX36	U					+
4	DKC1	H/ACA ribonucleoprotein complex subunit B	U	D		D		+
3	DPP3	Dipeptidyl-peptidase 3		D					+
3	DYNC1I2	Cytoplasmic dynein 1 intermediate chain 2						+
3	EBP2	Probable rRNA-processing protein, EBNA1BP2						+
4	ECH1	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial	U	D	U				+	[85]
2	EEF1A1	Elongation factor 1-alpha 1	U	D	U	D			+	[86]
2	EEF1A2	Elongation factor 1-alpha 2	U		U		Orf3	+		[87]
2	EEF1G	Elongation factor 1-gamma	U	D	U				+
3	EEF2	Elongation factor 2	U	D	U			+		[88]
16	EFTUD2	116 kDa U5 small nuclear ribonucleoprotein component		D		D		+		[89]
2	EIF2A	Eukaryotic translation initiation factor 2 subunit 1, EIF2							+
6	EIF3A	Eukaryotic translation initiation factor 3 subunit A	U	D		D		+		[90]
4	EIF3B	Eukaryotic translation initiation factor 3 subunit	U	D		D		+
3	EIF3CL	Eukaryotic translation initiation factor 3 subunit C-like protein		D		D		+
2	EIF3E	Eukaryotic translation initiation factor 3 subunit E	U	D	U			+		[91]
7	EIF3L	Eukaryotic translation initiation factor 3, subunit E interacting protein		D				+
13	EIF4A1	Eukaryotic initiation factor 4A-I, DDX2A	U	D	U	D			+
2	EIF5A	Eukaryotic translation initiation factor 5A-1	U	D	U	D			+	[92]
2	EMG1	Ribosomal RNA small subunit methyltransferase NEP1	U	D					+
3	ENO1	Isoform alpha-enolase of Alpha-enolase	U	D	U	D			+	[93]
6	EPHX1	Epoxide hydrolase		D		D		+		[94]
3	ESYT1	Extended synaptotagmin-1						+		[95]
3	EZR	Ezrin	U	D	U	D			+	[96]
3	FKBP4	FK506-binding protein, FKBP52							+	[97]
27	FLNA	Filamin-A	U	D	U	D		+		[98]
25	FLNB	Filamin-B	U		U				+	[3]
9	FLNC	Filamin-C	U	D				+		[99]
2	FTH1	Ferritin heavy chain	U	D	U	D			+	[100]
10	G6PD	Glucose-6-phosphate 1-dehydrogenase (anemia, diabetes)	U	D	U			+		[101]
5	GANAB	Neutral alpha-glucosidase A		D		D			+	[102]
2	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	U	D		D			+	[103]
2	GAR1	H/ACA ribonucleoprotein complex subunit 1						+
2	GBE1	1,4-alpha-glucan-branching enzyme	U						+
4	GCLC	Glutamate-cysteine ligase catalytic subunit (hemolytic anemia)					Orf3		+
6	GDI1	Rab GDP dissociation inhibitor alpha	U	D	U				+	[104]
7	GDI2	cDNA FLJ60299, highly similar to Rab GDP dissociation inhibitor beta	U	D	U				+	[105]
2	GLO1	Lactoylglutathione lyase (prostasome)		D			Orf3		+	[106]
2	GPC1	Glypican-1		D		D		+
2	GPI	Glucose-6-phosphate isomerase	U	D	U	D	Orf3		+	[107]
4	GRWD1	Glutamate-rich WD repeat-containing protein 1						+
6	GSTP1	Glutathione S-transferase	U	D		D			+	[108]
2	H2AFR	Histone H2A type 1-A, H2AC1, HIST1H2AA						+		[109]
3	H2AFV	Histone H2A.V, H2AZ2		D		D		+		[109]
11	H2AFY	H2A histone family, member Y isoform, MacroH2A1	U					+		[110]
2	H2AFY2	Core histone macro-H2A.2, MACROH2A2						+		[109]
4	HADHA	Trifunctional enzyme subunit alpha, mitochondrial						+
2	HARS	Histidyl-tRNA synthetase, cytoplasmic, HRS							+	[10]
4	HEATR1	HEAT repeat-containing protein 1	U	D	U	D		+
2	HIST1H1B	Histone H1.5, H1–5	U	D		D		+		[111]
6	HIST1H1C	Histone H1.2	U	D	U	D		+		[111]
2	HIST1H2BL	Histone H2B type 1-L, H2BC13	U	D	U	D		+		[112]
9	HIST1H4J	Histone H4, H4C1	U	D	U	D		+		[113]
12	HIST2H2BE	Histone H2B type 2-E, H2BC21	U	D		D		+		[114]
5	HIST2H3A	HIST2H3C, Histone H3.2, H3C15	U	D	U			+		[115]
3	HNRNPA2B1	Heterogenous nuclear ribonucleoproteins A2/B1	U	D					+	[116]
3	HNRNPC	Heterogeneous nuclear ribonucleoproteins C1/C2	U	D	U	D		+		[117]
6	HNRNPCL1	Heterogeneous nuclear ribonucleoprotein C-like 1						+
4	HNRNPF	Heterogeneous nuclear ribonucleoprotein F		D		D		+		[118]
2	HNRNPH1	Heterogeneous nuclear ribonucleoprotein H	U	D	U			+		[118]
3	HNRNPK	Heterogeneous nuclear ribonucleoprotein K	U						+	[119]
3	HNRNPM	Heterogeneous nuclear ribonucleoprotein M	U	D		D		+
4	HNRNPR	Heterogeneous nuclear ribonucleoprotein R	U	D	U				+	[120]
2	HNRNPU	Heterogeneous nuclear ribonucleoprotein U	U	D	U	D		+
6	HNRNPUL1	hnRNP U-like protein 1	U	D		D		+
4	HNRNPUL2	hnRNP U-like protein 2	U	D				+
4	HSP70T	Heat shock 70 kDa protein 1-like, HSPA1L							+
11	HSP90AA1	Heat shock 90 kDa protein 1, alpha isoform	U	D	U				+	[121]
3	HSP90AA2	Heat shock protein HSP 90-alpha A2	U	D	U			+		[122]
5	HSP90AB1	Heat shock protein HSP 90-beta	U	D	U				+	[123]
23	HSP90B1	Endoplasmin	U	D	U			+		[124]
7	HSPA1A	Heat shock 70 kDa protein 1A	U	D	U	D	N, Orf9b		+	[125]
35	HSPA5	HSPA5 protein, BiP, GRP78	U	D	U	D	Nsp2 Nsp4	+		[126]
2	HSP70B	Putative heat shock 70 kDa protein, HSPA7	U	D	U			+
20	HSPA8	Heat shock cognate 71 kDa protein	U	D	U		Nsp2	+		[127]
17	HSPA9	Stress-70 protein, mitochondrial	U	D		D	N		+	[127]
2	HSPBP1	Hsp70-binding protein	U	D					+	[128]
3	HSPG2		U	D	U			+		[129]
		Basement membrane-specific heparan sulfate proteoglycan core
		protein
4	HTATSF1	HIV Tat-specific factor 1		D		D		+
4	IDE	Insulin-degrading enzyme (insulin, amyloid)					Nsp4		+
2	IL18	Interleukin-18	U	D	U	D			+	[130]
5	ILF2	Interleukin enhancer-binding factor	U		U			+		[131]
9	IQGAP1	Ras GTPase-activating-like protein IQGAP1	U					+		[132]
4	ITGB1	Integrin beta-1	U	D		D	Nsp4 Orf8	+		[133]
2	IWS1	Protein IWS1 homolog	U	D	U	D		+
3	KARS	Lysyl-tRNA synthetase						+		[134]
10	KPNB1	Importin subunit beta-1, IPOB,						+		[135]
2	KRR1	KRR1 small subunit processome component homolog, HIV-1 Rev-binding protein						+		[136]
2	KYNU	Kynureninase	U		U		Orf3		+
2	LAMP2	Lysosome-associated membrane glycoprotein 2	U	D	U	D			+	[137]
2	LARS	Leucyl-tRNA synthetase, cytoplasmic						+		[134]
3	LCP1	Plastin-2	U	D					+	[138]
8	LDHA	L-lactate dehydrogenase	U	D	U	D			+	[139]
9	LDHB	L-lactate dehydrogenase B chain	U	D	U	D			+	[139]
2	LEO1	RNA polymerase-associated protein LEO1	U		U			+
6	LMNA	Lamin-A/C	U	D	U	D			+	[140]
2	LMNB2	Lamin-B	U	D				+		[141]
4	LRPPRC	Leucine-rich PPR motif-containing protein, mitochondrial		D					+	[142]
3	MAP1B	Microtubule-associated protein 1B	U	D	U	D		+		[143]
2	MARS	Methionyl-tRNA synthetase, cytoplasmic, SLA2		D		D		+
3	MDH2	Malate dehydrogenase, mitochondrial	U	D					+	[144]
4	MOV10	Helicase MOV-10, Moloney Leukemia virus 10 protein	U	D		D	N	+
5	MRPL1	39S ribosomal protein L1, mitochondrial						+
3	MRPL13	39S ribosomal protein L13, mitochondrial		D		D		+
2	MRPL15	39S ribosomal protein L15, mitochondrial	U	D		D		+
2	MRPL17	39S ribosomal protein L17, mitochondrial		D		D		+
2	MRPL18	39S ribosomal protein L18, mitochondrial		D		D		+
4	MRPL19	39S ribosomal protein L19, mitochondrial		D		D		+
2	MRPL2	39S ribosomal protein L2, mitochondrial		D		D		+
2	MRPL23	39S ribosomal protein L23, mitochondrial		D				+
5	MRPL37	39S ribosomal protein L37, mitochondrial	U	D		D		+
5	MRPL38	39S ribosomal protein L38, mitochondrial		D		D		+
2	MRPL39	39S ribosomal protein L39, mitochondrial		D		D		+
3	MRPL45	39S ribosomal protein L45, mitochondrial		D		D		+
2	MRPL49	39S ribosomal protein L49, mitochondrial		D		D		+
4	MRPS22	28S ribosomal protein S22, mitochondrial						+
4	MRPS23	28S ribosomal protein S23, mitochondrial						+
6	MRPS27	28S ribosomal protein S27, mitochondrial					Nsp8	+
2	MRPS28	28S ribosomal protein S28, mitochondrial, MRPS35						+
6	MRPS29	28S ribosomal protein S29, mitochondrial, DAP3						+
2	MRPS30	28S ribosomal protein S30, mitochondrial		D		D		+
2	MRPS34	28S ribosomal protein S34, mitochondrial		D				+
16	MRPS39	Pentatricopeptide repeat-containing protein 3, mitochondrial, PTCD3						+
3	MRPS9	28S ribosomal protein S9, mitochondrial						+
4	MSN	Moesin (membrane organizing extension spike protein)	U		U		Nsp6Orf3		+	[145]
12	MVP	Major vault protein	U	D	U			+		[146]
16	MYBBP1A	Myb-binding protein 1A	U	D	U			+
2	MYG1	UPF0160 protein MYG1, mitochondrial							+
14	MYH9	Myosin-9	U	D	U	D			+	[147]
2	MYO1E	Unconventional myosin-Ie, MYO1C	U					+		[148]
3	NAP1L1	Nucleosome assembly protein 1-like 1	U	D		D		+
18	NCL	Nucleolin	U	D				+		[149]
8	NME1	Nucleoside diphosphate kinase	U	D		D			+	[150]
3	NME2	Nucleoside diphosphate kinase 2, NM23	U	D					+	[151]
2	NOC2L	Nucleolar complex protein 2 homolog		D		D		+
9	NOP2	Probable 28S rRNA (cytosine(4447)-C(5)-methyltransferase	U		U			+
2	NPEPPS	Puromycin-sensitive aminopeptidase, metalloproteinase MP100							+
6	NPM1	Nucleophosmin	U	D	U	D		+		[152]
2	NRCAM	Neuronal cell adhesion molecule	U	D	U	D			+	[153]
4	NUDT21	Cleavage and polyadenylation specificity factor subunit 5		D		D			+
2	OLA1	Obg-like ATPase 1	U		U				+
11	P4HB	Protein disulfide-isomerase	U	D	U	D			+	[154]
22	PABPC1	Polyadenylate-binding protein 1		D		D	N	+		[155]
11	PABPC4	Polyadenylate-binding protein 4		D		D	N	+		[156]
4	PAF1	RNA polymerase II-associated factor 1 homolog		D				+
2	PAFAH1B2	Platelet-activating factor acetylhydrolase IB subunit beta	U	D	U	D			+
3	PAFAH1B3	Platelet-activating factor acetylhydrolase IB subunit gamma	U		U				+
6	PCNA	Proliferating cell nuclear antigen	U	D	U	D			+	[157]
12	PDIA3	Protein disulfide-isomerase A3	U	D	U		Orf8		+	[158]
18	PDIA4	Protein disulfide-isomerase A4	U	D	U				+
10	PDIA6	Protein disulfide-isomerase A6	U	D	U	D			+	[159]
6	PELP1	Proline-, glutamic acid-, leucine-rich protein 1		D		D		+
2	PES1	Pescadillo homolog		D				+
2	PFAS	Phosphoribosylformylglycinamidine synthase, GATD8, FGARAT, PURL							+
2	PFKP	ATP-dependent 6-phofructokinase, platelet type	U	D	U		Orf7a		+	[160]
2	PGAM2	Phosphoglycerate mutase, PGAMM							+
9	PGD	6-phosphogluconate dehydrogenase, decarboxylating	U	D	U				+
2	PLD3	Phospholipase D3, 5’−3’ exonuclease PLD3	U	D		D	Nsp2Orf8 Orf7b		+
39	PLEC	Plectin-1	U	D	U	D		+		[161]
2	PLS1	Plastin-1		D					+
5	PLS3	Plastin-3	U	D					+
2	POP1	Ribonucleases P/MRP protein subunit POP1	U					+		[162]
3	POR	NADPH-cytochrome P450 reductase	U	D	U		Nsp2	+
2	PPA1	Inorganic pyrophosphatase (Guillain-Barre syndrome)	U				Orf3		+	[163]
5	PPIB	Peptidyl-prolyl cis-trans isomerase	U	D	U				+	[164]
6	PRDX1	Peroxiredoxin-1	U	D	U	D			+	[165]
4	PRDX3	Thioredoxin-dependent peroxide reductase, mitochondrial	U	D	U				+	[166]
3	PRDX4	Peroxiredoxin-4	U	D					+	[167]
17	PRKDC	DNA-dependent protein kinase catalytic subunit	U	D	U		M Nsp4	+		[168]
3	PRMT1	HMT1, hnRNP methyltransferase-like 2 isoform		D		D			+
19	PRPF8	Pre-mRNA-processing-splicing factor 8	U	D	U	D		+		[3]
6	PSAT1	Phosphoserine aminotransferase 1	U	D	U		Orf3 Orf7a		+
2	PSMD1	26S proteasome non-ATPase regulatory subunit 1	U		U			+
2	PSMD6	26S proteasome non-ATPase regulatory subunit 6, PFAAP4							+
18	PUM1	Pumilio homolog 1		D		D		+
3	PURA	Transcriptional activator protein Pur-alpha	U	D	U	D		+
2	PURH	Bifunctional purine biosynthesis protein, ATIC							+	[169]
4	QARS	Glutaminyl-tRNA synthetase						+		[134]
3	RAB1A	Ras-related protein Rab-1A (intracellular membrane trafficking)		D			Nsp7 Orf3 Orf7b	+
6	RALY	RNA-binding protein, autoantigen p542	U	D	U	D		+		[170]
2	RANGAP1	Ran GTPase-activating protein 1		D				+		[171]
3	RARS	Arginyl-tRNA synthetase, cytoplasmic, RARS1	U		U			+
5	RBBP4	Histone-binding protein RBBP4		D				+		[172]
3	RBM8A	RNA-binding protein 8A	U					+
8	RDX	Radixin					Nsp13 Orf3		+	[173]
3	RNPEP	Arginine aminopeptidase, APB							+
2	RNPS1	RNA-binding protein with serine-rich domain 1	U	D	U	D		+
4	RO60	60 kDa SS-A/Ro ribonucleoprotein	U		U			+		[174]
3	RPF2	Ribosome production factor 2 homolog, BXDC1						+
4	RPL10A	60S ribosomal protein L10A, NEDD6						+
2	RPL11	60S ribosomal protein L11	U		U			+
4	RPL12	60S ribosomal protein L12	U	D	U			+		[175]
3	RPL15	60S ribosomal protein L15		D		D		+
3	RPL18	60S ribosomal protein L18		D		D		+
2	RPL26L1	60S ribosomal protein L26-like 1, RPL26P1						+
2	RPL35A	60S ribosomal protein L35a	U	D	U			+		[176]
2	RPL4	60S ribosomal protein L4	U	D	U	D		+
17	RPL5	60S ribosomal protein L5		D		D		+		[177]
11	RPL6	60S ribosomal protein L6	U	D	U	D		+		[178]
9	RPL7	60S ribosomal protein L7, RPL7P32	U	D	U	D		+		[179]
4	RPL7A	60S ribosomal protein L7A	U	D		D		+		[176]
2	RPL8	60S ribosomal protein L8	U	D	U	D		+		[171]
8	RPLP0	60S acidic ribosomal protein P0	U	D	U			+		[180]
2	RPLP1	60S acidic ribosomal protein P1	U	D		D		+		[181]
3	RPLP2	60S acidic ribosomal protein P2	U	D	U	D		+		[181]
2	RPS15A	40S ribosomal protein S15a	U					+
3	RPS18	40S ribosomal protein S18	U	D				+		[171]
3	RPS2	40S ribosomal protein S2	U	D	U	D		+
3	RPS3	40S ribosomal protein S3	U	D	U			+		[182]
4	RPS4X	40S ribosomal protein S4, X isoform		D		D		+
3	RPS6	40S ribosomal protein S6	U	D	U	D		+		[176]
2	RPS8	40S ribosomal protein S8	U	D	U			+
8	RPS9	40S ribosomal protein S9		D				+		[176]
4	RPSA	40S ribosomal protein SA, LMAR1							+	[183]
2	RRBP1	Ribosome-binding protein 1	U	D		D		+
11	RRP12	RRP12-like protein	U					+
3	RRP9	U3 small nucleolar RNA-interacting protein 2 (U3–55K)	U	D			N	+		[184]
4	RRS1	Ribosome biogenesis regulatory protein homolog	U		U			+
5	RSL1D1	Ribosomal L1 domain-containing protein 1	U	D	U			+
2	RUVBL1	RuvB-like 1						+		[185]
13	SAP130	Histone deacetylase complex subunit SAP130	U		U			+
5	SERPINB1	Leukocyte elastase inhibitor	U						+
4	SERPINB6	Serpin B6, peptidase inhibitor 6							+
2	SERPINC1	Antithrombin-III	U						+
6	SET	Protein SET, phosphatase 2A inhibitor	U	D		D		+
14	SF3B1	Splicing factor 3B subunit 1	U	D		D		+		[186]
8	SFN	14-3-3 protein sigma	U	D	U				+	[187]
2	SLC1A5	Neutral amino acid transporter B, Simian type D retrovirus receptor, Baboon M7 virus receptor	U	D	U			+
2	SLC2A1	HepG2 glucose transporter, human T-cell leukemia virus receptor, GLUT1		D		D	Nsp8	+		[188]
17	SLC3A2	4F2 cell-surface antigen heavy chain	U	D	U			+
2	SND1	Staphylococcal nuclease domain-containing protein 1	U	D		D			+
15	SNRNP200	U5 small nuclear ribonucleoprotein 200 kDa helicase		D		D		+		[189]
3	SNRPA	U1 small nuclear ribonucleoprotein A	U					+		[190]
2	SNRPB	Small nuclear ribonucleoprotein-associated proteins B and B’	U	D	U	D		+		[191]
2	SNRPD1	Small nuclear ribonucleoprotein Sm D1	U		U			+		[192]
4	SNRPD2	Small nuclear ribonucleoprotein Sm D2		D		D		+		[193]
2	SNRPG	Small nuclear ribonucleoprotein G, PBSCG						+		[194]
2	SOD1	Superoxide dismutase [Cu-Zn]	U	D					+	[195]
46	SPTAN1	Spectrin alpha chain, brain	U	D		D		+		[196]
29	SPTBN1	Spectrin beta chain, brain 1	U	D	U	D		+		[197]
2	SRP72	Signal recognition particle 72 kDa protein		D		D		+		[198]
3	SRSF1	Serine arginine rich splicing factor 1, ASF, SF2	U	D		D		+		[199]
6	SSB	Lupus La protein	U	D	U	D			+	[10]
9	SSBP1	Single-stranded DNA-binding protein, mitochondrial					N	+
8	SSRP1	FACT complex subunit SSRP1	U	D	U	D		+		[200]
2	ST13	Hsc70-interacting protein	U		U				+	[201]
9	SUPT16H	FACT complex subunit SPT16		D		D		+
2	SUPT5H	Transcription elongation factor SPT5						+
2	SYNCRIP	Heterogeneous nuclear ribonucleoprotein Q		D		D		+
11	TALDO1	Transaldolase	U	D	U	D			+	[202]
4	TEX10	Testis-expressed protein 10						+
3	TFG	TRK-fused gene protein							+
4	TGM2	Protein-glutamine gamma-glutamyltransferase 2	U	D	U	D			+	[203]
4	TLN1	Talin-1	U	D	U				+	[204]
3	TOP1	DNA topoisomerase 1	U					+		[205]
5	TP53I3	Quinone oxidoreductase	U	D	U	D			+
7	TPM1	Tropomyosin 1 alpha chain	U	D	U	D			+	[206]
2	TPM2	Tropomyosin beta chain	U	D	U	D			+
4	TPM3	Tropomyosin alpha-3 chain	U	D	U	D			+	[207]
8	TPM4	Tropomyosin alpha-4 chain	U	D	U				+	[208]
3	TSN	Translin		D		D			+
4	TUBA1C	Tubulin alpha-1C chain	U	D	U	D		+		[209]
5	TUBA4A	Tubulin alpha-4A chain	U	D		D		+		[210]
4	TUBB4B	Tubulin beta-2C chain, TUBB2C	U	D	U			+		[211]
2	TXNDC5	Thioredoxin domain-containing protein 5	U	D	U	D			+
15	TXNRD1	Thioredoxin reductase 1, cytoplasmic	U	D	U				+	[212]
7	UBA1	Ubiquitin-like modifier-activating enzyme 1	U	D	U	D			+	[213]
3	UBC	RPS27A; UBB ubiquitin-40S ribosomal protein S27a precursor	U	D				+		[214]
2	UBTF	Nucleolar transcription factor 1, autoantigen N0R-90		D		D		+		[215]
2	UCHL1	Ubiquitin carboxyl-terminal hydrolase isozyme L1	U	D	U	D	Orf3		+	[216]
5	UGDH	UDP-glucose 6-dehydrogenase	U	D	U				+
15	UPF1	Regulator of nonsense transcripts 1		D			N	+
2	USP7	Ubiquitin carboxyl-terminal hydrolase (Herpes virus associated)	U		U			+
27	VCL	Vinculin	U	D	U				+	[217]
18	VCP	Transitional endoplasmic reticulum ATPase	U	D	U	D			+	[218]
11	VIM	Vimentin	U	D	U	D		+		[219]
5	WDR18	WD repeat-containing protein 18		D				+
32	XRCC5	ATP-dependent DNA helicase 2 subunit 2		D		D		+		[220]
30	XRCC6	ATP-dependent DNA helicase 2 subunit 1	U	D	U	D		+		[221]
3	YBX1	Y-box-binding protein 1	U	D	U	D		+		[222]
6	YBX3	Y-box binding protein 3, CSDA	U	D	U	D		+		[223]
5	YWHAB	14-3-3 protein beta/alpha	U	D		D			+
15	YWHAE	14-3-3 protein epsilon	U	D	U	D			+	[187]
6	YWHAG	14-3-3 protein gamma	U	D					+	[187]
3	YWHAH	14-3-3 protein eta		D					+	[224]
7	YWHAQ	14-3-3 protein theta	U	D	U				+	[183]
7	YWHAZ	14-3-3 protein zeta/delta	U	D		D			+	[225]

Notes: # Pep.: number of peptides identified by mass spectrometry; COVID (up/down): protein or gene expression up- and/or down-regulated in SARS-Cov-2 infected cells or patients; A549 infection (up/down): protein or gene expression up- and/or down-regulated in SARS-Cov-2 infected A549 cells; Interactome: host protein interacting with SARS-CoV-2 protein; DS-affinity: concentration of NaCl (1.0 M, strong affinity, or 0.5 M, intermediate affinity) at which a DS-binding protein elutes from DS-affinity resin.