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. Author manuscript; available in PMC: 2021 May 14.
Published in final edited form as: Cell Host Microbe. 2021 Apr 2;29(5):792–805.e6. doi: 10.1016/j.chom.2021.03.001

Figure 7. Model for silencing of unintegrated HIV-1 by the SMC5/6 complex.

Figure 7.

(A) Schematic of model: (Ai) in the absence of antagonism by Vpr, the SMC5/6 complex is recruited to unintegrated HIV-1 genomes in an SLF2-dependent manner. (Aii) This leads to compaction of viral chromatin by either topological or pseudotopological entrapment of DNA. A repressive chromatin environment is created, and viral gene expression is silenced. (Aiii) HIV-Vpr degrades SLF2 to antagonize restriction by the SMC5/6 complex, thereby rescuing gene expression from unintegrated viral genomes.