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. Author manuscript; available in PMC: 2021 May 18.
Published in final edited form as: Addict Biol. 2020 Oct 19;26(3):e12973. doi: 10.1111/adb.12973

FIGURE 1.

FIGURE 1

Experimental design of the study. A, Timeline of behaviors and jugular catheter surgeries (“catheter”, d22). Days are numbered sequentially starting with the first day of morphine injections and ending on the last day of PR. B, Escalating dose morphine regimen: 2 injections per day (10:00 and 16:00) for 12 days (12d), with doses increasing from 5 to 30 mg/kg/injection, IP. AS, acoustic startle; DR, dose response; inj, injection; Morph, morphine; Oxy, oxycodone; Prep, Preparation; Prog Ratio, progressive ratio; SA, self-administration; SW, somatic withdrawal; TF, tail flick; Veh, vehicle