Skip to main content
. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Genes Brain Behav. 2021 May 19;21(1):e12739. doi: 10.1111/gbb.12739

Figure 5. Transgenic MECP2 supplementation leads to an MDS-like motor coordination phenotype in female R294X mice.

Figure 5.

(A) Female R294X mice have reduced motor coordination in the rotarod assay, while female TG mice have enhanced motor coordination, compared to WT littermates. Motor coordination of female R294X TG mice is elevated compared to WT. (Colors as in Figure 1. Age: 31 weeks. WT n=15; R294X n=17; TG n=16; R294X TG n=15) (B-C) In the forced gait assay, front paw stride length in millimeters (B) is increased in both female TG and R294X TG mice compared to WT littermates. Rear paw stride length (C) is increased in female R294X TG mice compared to WT littermates. (Age: 34-40 weeks. WT n=15; R294X n=17; TG n=16; R294X TG n=14) (D) There are no differences in body weights of female R294X,TG, or R294X TG mice compared to WT littermates. (Age: 34-40 weeks. WT n=15; R294X n=16; TG n=16; R294X TG n=15) (E) The body length of female R294X mice is decreased relative to WT littermates, while body length of female TG mice is relatively increased. Body length of female R294X TG mice is not different from that of WT. (Age: 34-40 weeks. WT n=15; R294X n=16; TG n=16; R294X TG n=15)