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Location of the second substrate (a and b) probes 7 and 8 used in model building studies. Several rotamers about the C-1′–C-4 bond (red) were considered. (c) PRPP sits in a large positively charged pocket that could also bind the negatively charged ADPA molecule. The binding pocket is shown as an electrostatic surface. (d) The active site pocket is lined by several polar residues, coloured as in Fig. 2d.
