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(a) Overlay of PRPP in the ForT/PRPP complex with AMP-PNP homoserine kinase complex. The proximal pyrophosphate of PRPP overlaps with the γ-phosphate of AMP-PNP. (b) The transition state for γ-phosphoryl transfer in the reaction catalysed by homoserine kinase. (c) Proposed mechanism for ForT-catalysed C–C bond formation. Note that the configuration of the correct epimer at the new stereogenic centre remains to be established.
