Library of drug-loaded CDN nanoparticles. The average experimental drug loading values of various small molecules for CDNs 1–4 are shown for a theoretical loading of 10% (w/w), including an assortment of HDACi and non-HDACi molecules: (A) quisinostat, (B) panobinostat, (C) dacinostat, (D) givinostat, (E) bortezomib, (F) camptothecin, and (G) nile red. Molecular structures of compounds illustrate the hydrophobic (red) and terminally ionizable (green) moieties. Error bars are reported as the standard deviation of three separate experimental repeats.