Table 3. Insulin, C-peptide, glucose, blood pressure, and heart rate at the day of the meal-test and the peptide test.
Insulin, C-peptide, glucose, blood pressure, and heart rate at the day of the liquid meal-test and the peptide-test. Data are presented as mean±SEM baseline and peak/nadir values as relevant.
| Meal-test (n = 7) |
Peptide-test (n = 4) |
||||
|---|---|---|---|---|---|
| GIP | GLP-2 | Placebo | |||
| Insulin (pmol/L) | Baseline | 47 ± 6.3 | 53 ± 5.7 | 37 ± 3.3 | 32 ± 2.7 |
| Peak | 262 ± 82 | 77 ± 11 | 44 ± 6.8 | 32 ± 3.7 | |
| C-peptide (pmol/L) | Baseline | 501 ± 43 | 530 ± 72 | 451 ± 41 | 399 ± 29 |
| Peak | 1536 ± 325 | 639 ± 80 | 447 ± 64 | 404 ± 48 | |
| Glucose (mmol/L) | Baseline | 5.0 ± 0.1 | 5.2 ± 0.1 | 5.0 ± 0.1 | 5.0 ± 0.0 |
| Peak/Nadir | 6.2 ± 0.5 peak | 4.6 ± 0.3 nadir | 4.9 ± 0.2 nadir | 4.7 ± 0.1 nadir | |
| Systolic blood pressure (mmHg) | |||||
| Baseline | 143 ± 6.7 | 135 ± 9.1 | 130 ± 8.3 | 133 ± 5.9 | |
| Nadir | 127 ± 6.1 | 121 ± 9.2 | 118 ± 12 | 128 ± 12 | |
| Diastolic blood pressure (mmHg) | |||||
| Baseline | 85 ± 4.4 | 77 ± 4.3 | 70 ± 1.1 | 73 ± 2.6 | |
| Nadir | 75 ± 6.8 | 75 ± 8.5 | 67 ± 6.6 | 68 ± 3.8 | |
| Heart rate (bpm) | Baseline | 66 ± 4.6 | 67 ± 2.7 | 66 ± 3.1 | 62 ± 2.2 |
| Peak | 71 ± 4.8 | 71 ± 3.5 | 70 ± 3.2 | 63 ± 4.4 | |
| CTX (ng/mL) | Baseline | 0.45 ± 0.15 | 0.30 ± 0.10 | 0.37 ± 0.06 | 0.32 ± 0.09 |
| Nadir | 0.21 ± 0.05 | 0.25 ± 0.16 | 0.27 ±0.20 | 0.31 ± 0.19 | |
| P1NP (pg/mL) | Baseline | 60.9 ±13.7 | 37.3 ± 12.2 | 38.2 ± 13.5 | 39.7 ± 12.2 |
| Peak | 65.8 ± 15.4 | 44.6 ± 21.7 | 38.9 ± 14.7 | 44.5 ± 17.0 | |
| Nadir | 59.5 ± 14.0 | 26.2 ± 18.1 | 35.4 ± 10.6 | 38.9 ± 10.7 | |