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. Author manuscript; available in PMC: 2021 Nov 3.
Published in final edited form as: Clin Cancer Res. 2021 Jun 14;27(21):5742–5752. doi: 10.1158/1078-0432.CCR-21-0206

Table 1:

Overview of CD4 populations and their contributions to tumor immunity. Tbet: T-box expressed in T-cells; IFNγ: interferon gamma; GATA3:GATA binding protein 3; IL: interleukin; RORγt: retinoic-acid-receptor-related orphan nuclear receptor gamma; FoxP3: Forkhead Box P3; TGFβ: transforming growth factor beta; Runx3: RUNX Family Transcription Factor 3.

T-cell
subset		 Master
regulator		 Cytokine Functions within the tumor
Th1 Tbet IFNγ

  • Activate macrophages to phagocytose

  • Promote recruitment of antigen presenting cells

  • Enhance CD8 effector function

  • Inhibit angiogenesis
Th2 GATA3 IL4, IL5, IL13

  • Recruit eosinophils

  • Inhibit antigen processing by dendritic cells
Th17 RORγt IL17

  • Promote angiogenesis

  • Recruit neutrophils
Regulatory T-cell FoxP3 IL10, TGFβ

  • Decrease effector functions of tumor-infiltrating T-cells
Cytotoxic CD4 T-cells Runx3 Perforin, Granzymes

  • Direct tumor cytotoxicity