. Author manuscript; available in PMC: 2021 Sep 22.

Published in final edited form as: Oncogene. 2021 Jul 16;40(35):5379–5392. doi: 10.1038/s41388-021-01914-2

Table 1.

PK parameters of ARVib in SD rats’ plasma

Pharmacokinetic parameters	Nic p.o. (200 mg/Kg)	ARVib-7 p.o (200 mg/Kg)	ARVib-31 p.o (200 mg/Kg)
HL_Lambda_z (min)	328.09±173.05	580.54±86.4	276.51±92.17
T _max (min)	25.00±8.66	22.5±10.61	25±8.66
C_max (nM)	1556.93±974.31	9038.31±8015.51	2685.82±1796.25
Clast	14.41±10.83	311.67±46.8	15.24±5.73
AUClast	248249.95±91856.79	1439633.38±89486.89	382230.2±220077.03
AUCINF_obs	1703577.65±89354.18	256881.89±167532.07	388512.79±217228.83
AUC_%Extrap_obs	3.67±3.73	15.35±3.08	2.3±1.85