Table 2:

Estimated covariate effects (95% confidence intervals) based on the model that included a linear term for age with random intercept, random slope and exponential correlation function and the model that included age using a spline with 5 knots, random intercept and exponential correlation function.

	US		UK
	Linear function	Spline	Linear function	Spline
Sex= male	1.42 (0.70, 2.14)	1.80 (1.04, 2.55)	2.5 (1.33, 3.7)	2.71 (1.49, 3.93)
Age at diagnosis	0.59 (0.43, 0.74)	0.57 (0.42, 0.72)	0.62 (0.30, 0.95)	0.6 (0.28, 0.92)
Year of birth	0.37 (0.30, 0.43)	0.42 (0.35, 0.48)	0.24 (0.13, 0.35)	0.3 (0.19, 0.41)