Figure 1: CISH is highly and constitutively expressed in tissue resident ILC2s.
a. RNA sequencing of purified ILC2s from indicated tissues. Legend colors indicate counts per million reads.
b. Induction of Il5 and Il13 but not Cish in cultured ILC2s from lung or SI treated with 10 ng/mL of IL-25 or IL-33, or PMA/ionomycin.*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 for one-way ANOVA with Dunnett testing for multiple comparisons. n = 3 wells/stimulation, each derived from a single pool of ILC2s isolated from 6 mice.