TABLE 1.
Polypoid degeneration protein assignments, obtained by peptide mass fingerprinting. Proteins are listed in order of descending MOlecular Weight SEarch (MOWSE) score, with a lower cut-off of 75. The MOWSE score reflects the statistical confidence of the protein assignment and is defined as −log10 P of the assignment occurring by chance
| Protein name | UniProt accession number | Gene symbol | MOWSE score | Sequence coverage (%) |
|---|---|---|---|---|
| Interferon-induced helicase C domain-containing protein 1 | Q9BYX4 | IFIH1 | 437 | 4.2 |
| BRCA1-associated protein | Q7Z569 | BRAP | 300 | 5.1 |
| Guanine nucleotide-binding protein G(T) subunit γ-T1 | P63211 | GNGT1 | 290 | 31.1 |
| Zinc finger protein 57 homolog | Q9NU63 | ZFP57 | 280 | 9.3 |
| Heat shock protein β−1 | P04792 | HSPB1 | 270 | 25.9 |
| Regulator of G-protein signalling 11 | O94810 | RGS11 | 243 | 4.3 |
| α-crystallin A chain | P02489 | CRYAA | 227 | 15.6 |
| Coiled-coil domain-containing protein 186 | Q7Z3E2 | CCDC186 | 199 | 6.1 |
| Susceptibility protein NSG-x | Q9UH64 | CDKN2A-DT | 182 | 27.8 |
| GEM-interacting protein | Q9P107 | GMIP | 176 | 4 |
| Graves disease carrier protein | P16260 | SLC25A16 | 172 | 13 |
| Keratin, type II cytoskeletal 1b | Q7Z794 | KRT77 | 167 | 8.8 |
| Zinc finger protein 493 | Q6ZR52 | ZNF493 | 154 | 9.3 |
| Dual specificity protein phosphatase 4 | Q13115 | DUSP4 | 145 | 5.3 |
| Myotubularin-related protein 6 | Q9Y217 | MTMR6 | 144 | 11.4 |
| Guanine nucleotide exchange protein SMCR8 | Q8TEV9 | SMCR8 | 143 | 4.8 |
| Opsin-5 | Q6U736 | OPN5 | 138 | 5.4 |
| Myoneurin | Q9NPC7 | MYNN | 138 | 4.6 |
| Metastasis-associated in colon cancer protein 1 | Q6ZN28 | MACC1 | 138 | 5.3 |
| UPF0258 protein KIAA1024 | Q9UPX6 | MINAR1 | 134 | 5.6 |
| SRR1-like protein | Q9UH36 | SRRD | 134 | 12.4 |
| Methionine--tRNA ligase, cytoplasmic | P56192 | MARS1 | 126 | 3.4 |
| Synaptotagmin-6 | Q5T7P8 | SYT6 | 123 | 6.3 |
| Phostensin | Q6NYC8 | PPP1R18 | 122 | 5.9 |
| HLA class I histocompatibility antigen, B-58 α chain | P10319 | HLA-B | 120 | 11.3 |
| Rho-related BTB domain-containing protein 1 | O94844 | RHOBTB1 | 118 | 9.1 |
| Sciellin | O95171 | SCEL | 95 | 5.8 |
| Seizure protein 6 homolog | Q53EL9 | SEZ6 | 92 | 4.2 |
| Fibrinogen C domain-containing protein 1 | Q8N539 | FIBCD1 | 91 | 4.8 |
| Sulfotransferase 1A2 | P50226 | SULT1A2 | 81 | 16.6 |
| E3 ubiquitin/ISG15 ligase TRIM25 | Q14258 | TRIM25 | 77 | 3.3 |
| Protein SIX6OS1 | Q8N1H7 | SIX6OS1 | 71 | 7.5 |
| PCI domain-containing protein 2 | Q5JVF3 | PCID2 | 75 | 9.3 |