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. Author manuscript; available in PMC: 2021 Aug 4.
Published in final edited form as: HGG Adv. 2021 Jun 12;2(3):100041. doi: 10.1016/j.xhgg.2021.100041

Table 2.

Genomic regions with statistically significant local genetic correlations between cancers

Cancer site 1 Cancer site 2 Region Region start Region end No. of SNPs Direction p valuea
ER-negative breast prostate 1q32 203334734 204681068 2,364 negative 3.45E–06
Colorectal prostate 4q24 105305294 107501305 2,986 positive 1.05E–05
Glioma prostate 5p15.33 982252 2132442 2,631 negative 4.03E–19
Colorectal glioma 5p15.33 982252 2132442 2,465 negative 1.24E–05
ER-negative breast prostate 5p15.33 982252 2132442 3,111 negative 1.90E–05
ER-negative breast glioma 5p15.33 982252 2132442 2,631 positive 2.40E–05
Melanoma pancreatic 5p15.33 982252 2132442 2,849 positive 4.85E–06
Lung pancreatic 5p15.33 982252 2132442 2,935 negative 1.39E–07
Overall breast colorectal 5q11.2 55417349 56621102 2,131 positive 1.97E–05
Colorectal prostate 8q24 126410917 128659111 4,275 positive 1.97E–16
ER-positive breast prostate 10q26.13 123231465 123900545 1,481 negative 1.22E–06
Endometrial prostate 17q12 34469036 36809344 2,748 positive 5.01E–09
ER-negative breast ovarian 19p13.11 16374416 18409862 4,103 positive 1.11E–07

Local genetic correlation between cancers across the genome (N = 1,703 regions) was estimated using HESS.

a

Cutoff of the statistical significance was defined as p < 0.05/1,703 = 2.94E–05, after adjusting for multiple comparison.