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. Author manuscript; available in PMC: 2021 Nov 23.
Published in final edited form as: Lab Invest. 2021 Aug 30;101(12):1605–1617. doi: 10.1038/s41374-021-00644-z

Figure 5. Tauopathy samples demonstrate low seeding potential compared to AD.

Figure 5

(a) Tau biosensor cells were seeded with aliquots of cortical P2 from normal controls (NL1, NL2; white), tauopathy cases without plaques (Braak III-IV, plaque 0; T1–5; grey), and AD cases (Braak III-VI, plaque B,C; AD 6–8; black), with lipofectamine control (Lipo). Integrated FRET density (Int FRET den). Seeding activity was increased in tauopathy and in AD compared to controls; **p<0.01, one-way ANOVA (b) Soluble Aβ42 was measured in the P2 from the same cases used in (a). (c) Correlation analysis of Aβ42 level and integrated FRET density.