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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Circ Genom Precis Med. 2021 Jul 16;14(4):e003288. doi: 10.1161/CIRCGEN.120.003288

Figure 1.

Figure 1.

Figure 1.

Associations between top candidate SNPs and HDL-C and TG concentrations stratified by category of SSB intake in a meta-analysis of the CHARGE cohorts and the UKB. A) In a random effects meta-analysis of the CHARGE cohorts and the UKB, the association of the minor allele at rs71556729 with HDL-C concentrations was observed only among the highest SSB consumers [β (95% CI): 2.12 (1.16, 3.07) mg/dl, p<0.0001], and not the lowest SSB consumers (p=0.81; pDiff<0.0001); B) In a random effects meta-analysis of the CHARGE cohorts and the UKB, the association of the minor allele at rs55673514 with TG concentrations was observed only among the highest SSB consumers [β (95% CI): 0.06 (0.02, 0.09) ln-mg/dl, p=0.001], and not the lowest SSB consumers (p=0.84; pDiff<0.0005); Linear regression models represent associations between each additional effect allele and HDL-C (mg/dl) or TG (ln-mg/dl) concentrations among SSB consumption categories accounting for family, population structure, and/or field center (where applicable) and adjusting for age, sex, total energy intake, education, smoking, physical activity, alcohol intake, and body mass index. Intake categories are different for the highest SSB consumers (CHARGE: >1 serving/day; UKB: SSB consumers) and lowest SSB consumers (CHARGE: <1 serving/month; UKB: SSB non-consumers) in the two samples. CI, confidence interval; CHARGE, Cohorts for Heart and Aging Research in Genetic Epidemiology; HDL-C, high-density lipoprotein cholesterol concentrations; I2, percentage of variance in a meta-analysis that is attributable to study heterogeneity; SSB, sugar-sweetened beverage consumption; TG, triglyceride concentrations; UKB, UK Biobank.