TABLE 2.
Demographic, clinical, and pathologic characteristics of subjects with and without LATE-NC
| Characteristics | No LATE-NC (n = 340) |
LATE-NC (n = 409) |
p-values* | Stage 1 (n = 147) |
Stage 2 (n = 75) |
Stage 3 (n = 187) |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age at death, mean (SD) years | 88.8 (6.6) | 91.4 (5.9) | <0.001 | 90.5 (6.4) | 91.3 (5.7) | 92.2 (5.4) |
| Female, n (%) | 225 (66.1) | 290 (70.9) | 0.164 | 96 (65.3) | 58 (77.3) | 136 (72.7) |
| Education, mean (SD) years | 16.2 (3.7) | 15.8 (3.3) | 0.121 | 15.7 (3.3) | 16 (3.8) | 15.9 (3.2) |
| Clinical | ||||||
| MMSE score, mean (SD) | 22.8 (8) | 18.1 (9.8) | <0.001 | 20.3 (9.5) | 19.7 (9.4) | 15.8 (9.9) |
| AD Dementia, n (%) | 110 (32.3) | 221 (54.1) | <0.001 | 57 (39) | 35 (46.6) | 129 (68.9) |
| aAPOEε4, n (%) | 62 (18.5) | 124 (31) | <0.001 | 36 (25) | 21 (28.4) | 67 (36.8) |
| Vascular risk factors burden, mean (SD) | 1.2 (0.9) | 1.1 (0.8) | 0.546 | 1.1 (0.8) | 1.1 (0.8) | 1.1 (0.8) |
| Vascular disease burden, mean (SD) | 0.7 (0.8) | 0.7 (0.8) | 0.343 | 0.7 (0.8) | 0.8 (0.9) | 0.6 (0.8) |
| Vascular and neuropathologic | ||||||
| AWS arteriolosclerosisd, n (%) | 150 (44.1) | 195 (47.6) | 0.330 | 70 (47.6) | 29 (38.7) | 96 (51.3) |
| bBG arteriolosclerosisd, n (%) | 101 (29.7) | 132 (32.3) | 0.436 | 47 (32.2) | 21 (28) | 64 (34.2) |
| PWS arteriolosclerosisd, n (%) | 101 (29.7) | 144 (35.2) | 0.110 | 48 (32.6) | 23 (30.7) | 73 (39) |
| cCAAd, n (%) | 102 (30.3) | 170 (41.5) | 0.001 | 54 (36.7) | 28 (37.3) | 88 (47.1) |
| Microinfarcts, n (%) | 124 (36.5) | 150 (36.6) | 0.953 | 59 (40.1) | 21 (28) | 70 (37.4) |
| Atherosclerosisd, n (%) | 79 (23.2) | 99 (24.2) | 0.756 | 36 (24.4) | 18 (24) | 34 (18.1) |
| Macroinfarcts, n (%) | 132 (38.8) | 133 (32.5) | 0.072 | 46 (31.2) | 15 (20) | 72 (38.5) |
| AD (NIA-Reagan), n (%) | 196 (57.6) | 303 (74.1) | <0.001 | 97 (65.9) | 48 (64) | 158 (84.4) |
| AD pathology score, mean (SD) | 0.6 (0.5) | 0.8 (0.6) | <0.001 | 0.7 (0.6) | 0.8 (0.7) | 0.9 (0.6) |
| Lewy bodies, n (%) | 71 (20.8) | 125 (30.6) | 0.002 | 43 (29.2) | 27 (36.4) | 55 (29.4) |
| Hippocampal sclerosis, n (%) | 3 (0.9) | 67 (16.4) | <0.001 | 3 (2) | 7 (9.3) | 57 (30.5) |
Abbreviations: AD, Alzheimer’s Disease; PWS, posterior watershed; APOE, apolipoprotein; AWS, anterior watershed; BG, basal ganglia; CAA, cerebral amyloid angiopathy; LATE-NC, limbic predominant age-related TDP-43 encephalopathy neuropathological change; MMSE, Mini-Mental-State-Examination.
a
Data missing for 14 participants.
b
Data missing for 1 participant.
c
Data missing for 3 participants.
d
Grade of moderate-to-severe.
*
p-values are comparing persons with and without LATE-NC (i.e., stage 0 vs. stage 1, stage 2, and stage 3)