Table 2.

Summary of neuronal and neuropathological data of the primary motor cortex^a.

	Control	HPC	AD	P-valueb
Cortical thickness (mm)	2.7 ± 0.4	3 ± 0.5	3 ± 0.4	0.3
Total neurons (‘000/mm3)c	24.8 ± 5.9	35.6 ± 12.1	33.1 ± 8	0.05
Betz cells (/mm3)d	726.8 ± 372.5	943.7 ± 148.8	636.8 ± 265.7	0.2
% Aβ	0.1 ± 0.1	0.3 ± 0.3	0.7 ± 0.2	0.0009
Total Aβ plaques (/mm3)	3.1 ± 4.8	4.6 ± 3.6	13.7 ± 4.7	0.003
Fibrillar (/mm3)	1.6 ± 2.2	2.2 ± 2.4	7.7 ± 4.3	0.001
Dense-cored (/mm3)	1.5 ± 3.2	2.2 ± 2.2	6 ± 2.8	0.006
% TTau	0.003 ± 0.003	0.002 ± 0.003	0.9 ± 0.6	0.004
NFTs (mm3)	0 ± 0	0 ± 0	11.8 ± 10.2	0.0004

^aMean ± standard deviation.

^bANOVA results; see text for p-values of pairwise comparisons.

^cInclusive of Betz cells.

^dDensity of Betz cells in layer V.