Skip to main content
. Author manuscript; available in PMC: 2021 Nov 16.
Published in final edited form as: Nat Methods. 2021 Sep 3;18(9):1046–1055. doi: 10.1038/s41592-021-01248-7

Figure 6: Hi-C 3.0 detects both compartments and loops.

Figure 6:

a. Distance dependent contact probability of interactions detected with 5 protocols in HFFc6 (trans percent is shown in dashed lines).

b. Derivative of the P(s) plots from panel a.

c. Overlapping loops between FA+DSG-DdeI+DpnII and FA+DSG-MNase.

d. Number of loops detected within 100kb intervals (loop size) starting at 70kb.

e. Loop strength of 1,000 loops sampled from 100 kb intervals (Figure 6d). When less than 1,000 loops were available, loop strengths for available loops were used.

f. A-A and B-B compartment strengths in cis and trans derived by saddle plot analysis.

g. Number of loops and compartment strength for 5 protocols applied to HFFc6.

h. Compartment strength compared to loop enrichment for 10,000 loops sampled from HFFc6 (2,000 loops were sampled from each protocol).

i. Compartment strength for 12 protocols applied to HFF compared to loop enrichment of 10,000 loops (panel h) using data from the same 12 protocols.