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. Author manuscript; available in PMC: 2022 Apr 26.
Published in final edited form as: RSC Adv. 2021 May 17;11(29):17809–17827. doi: 10.1039/d1ra02557k

Fig. 2.

Fig. 2

Stages of craniomaxillofacial bone defect regeneration with biomaterial implants and the possible routes of failure. Full regeneration of these defects can occur over the course of years and from the early to late stages of regeneration there are multiple instances of regeneration failure and when any of these failures occur, the biomaterial most likely will need to be removed and regeneration restarted with a new surgery and material.