Figure 3. Increased GDNF influences some aspects of myenteric plexus morphogenesis.
NADPH-d myenteric neuron fibers have a higher density around enteric ganglia in GFAP-Gdnf mice (E) than WT animals (A), but mice injected with GDNF (F) do not have an increase in NADPH-d stained neuronal fibers around enteric ganglia compared to controls (B). Tryptophan hydroxylase (C, G) and acetylcholinesterase (D, H) stained myenteric plexus in WT (C, D) and GFAP-Gdnf transgenic mice (G, H) appear similar. Scale bar (100 μm).